pentobarbital will reduce the extent or impact of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Mysterious.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can reduce panobinostat degrees by ~70% and result in